Squalene plays critical role in reduction of skin’s free radical oxidative damage
Squalene appears to be critical in reducing free radical oxidative damage to the skin. Although epidemiological, experimental, and animal evidence suggests antitumor properties, few human trials have been conducted to date to verify the role of squalene in cancer therapy. Further studies are needed to explore the usefulness of squalene for treating skin. Several implications can be drawn from this review. Squalene shows several advantages for skin tissues. It is also useful as a material in topically applied vehicles. Substances related to squalene such as β-carotene, coenzyme Q10, and vitamins A, E, and K also exhibit their benefits for skin physiology. Topical administration via the skin is an important route to supplement these compounds within skin tissues. The present success of squalene and its analogs shows the promise of further clinical trials for skin use.
